telehealth glp-1 crackdown news FDA Puts Pressure on Compounders, Providers The GLP-1 drug shortage is

280 , E443E449 (2001)

doi:10.1016/j.cca.2019.09.010 Dewailly D, Barbotin AL, Dumont A, Catteau-Jonard S, Robin G

The goal is choosing sweets that don't crash your blood sugar, like fruit, dark chocolate, or a protein-forward treat, rather than treating any sugar as off-limits

Beyond its canonical role in Gs/cAMP signaling, GLP-1R is increasingly recognized as an organizer of spatiotemporally defined signaling nanodomains, or signalosomes. This Review highlights our current knowledge on the mechanisms of assembly and regulation of GLP-1R signalosomes, including the involvement of biomolecular condensates formed by liquid-liquid phase separation, and the role of membrane contact sites between the endoplasmic reticulum (ER) and other organelles as key locations for GLP-1R signaling assemblies