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Beyond survodutide, the obesity pipeline includes: CagriSema (cagrilintide plus semaglutide): Novo Nordisk dual mechanism with phase 3 data showing about 22.7% weight loss Retatrutide: Eli Lilly triple agonist (GLP-1/GIP/glucagon) with phase 2 showing up to 24.2% weight loss at 48 weeks Orforglipron: Eli Lilly oral non-peptide GLP-1, in phase 3 with phase 2 showing about 14.7% weight loss Amycretin: Novo Nordisk oral amylin plus GLP-1, early data showing 13.1% loss at 12 weeks MariTide (maridebart cafraglutide): Amgen monthly GLP-1/GIP-antagonist with phase 2 data emerging Several of these may approve in 2026 or 2027, creating significantly more options than exist today

The total can be $1,800 or more, including the penalty assessments

Cho SG, Lee YH, Park HS, Ryoo K, Kang KW, Park J et al