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GLP-1 receptor agonists were initially developed to improve glycemic control in type 2 diabetes by enhancing insulin secretion and inhibiting glucagon release, with additional effects on appetite regulation and gastric emptying later recognized as clinically relevant (Chao et al

Last, to assess NAFLD progression, experiments were performed in 16- to 28-week-old mice fed an HFHC diet for 24 weeks, with sacrifice and tissue collection at 4052 weeks

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A patient who begins GLP-1 therapy often experiences significant fatigue, nausea, and reduced appetite in the early weeks