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MSA as a ligand was generated by addition of a hydroxy group to succinic semialdehyde (SSA) using Maestro (Schrdinger Suite 20234, Schrdinger, LLC), subsequent to the extraction of SSA from human SSA-DH [PDB: 2W8Q, (Kim et al., 2009)] superimposed with MSA-DH

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These findings also indicate that, at least at the central level, agonism of the GIP receptor exerts a catabolic action, suggesting that the reduction in body weight found in other studies after the administration of GIP receptor antagonists was not mediated by the brain

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