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Beginning in 2005, CMS allowed states to claim federal matching funds for certain existing, state-funded programs that would not otherwise qualify designated as DSHPs

It shares sequence and structural homology to thioredoxin reductase, and is a flavin-containing oxidoreductase

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and genetic factors, such as the Thr92Ala polymorphism in the DIO2 gene (rs225014) which is found in 1236% of the population (15)