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Consequently, succinate dehydrogenase (SDH) reverses its catalytic direction, reducing fumarate to succinate using electrons from reduced ubiquinone, leading to substantial succinate accumulation (up to 10-fold increases) within minutes

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Finally, we note that the model predicts modest decreases in the rate of the DNA methylation reaction (vDNMT) and this is consistent with the reported global DNA hypomethylation seen in autistic children [73]

However, as the overexpression of MUP1 and MMP1 appears to also decrease cytosolic acidification of CYS4 -OE cells (Supplementary Figure 1A), their action may also involve other molecular mechanisms