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A secondary endocrine disorder involves a problem with the regulatory signal coming from outside the gland, in this case, the pituitary gland or the hypothalamus, failing to properly stimulate the thyroid to produce its hormones

FEBS Lett 211(2):169174 Holter MM, Saikia M, Cummings BP (2022) Alpha-cell paracrine signaling in the regulation of beta-cell insulin secretion

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[53] The mechanism of action for Rimonabant was cannabinoid receptor CB1 antagonism, in other words, blocking the cannabinoid receptor (the one that weed, for example, binds to and activates in order to make you all happy)