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Alcohol use disorder Alcohol use disorder (AUD) contributes substantially to the world-wide mortality and morbidity ( For a multifaceted disorder like AUD, one animal model cannot be used to reflect its complexity, but can rather be used together to reflect aspects thereof [for extensive review see ( These preclinical models have been used in attempts to define the complex pathophysiology of the AUD process, where the multifaceted neurobiological processes of each of these stages has to be studied and various players have been defined

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Shoemaker's research demonstrated that patients with CIRS consistently show severe abnormalities in inflammatory blood markers, including highly elevated TGF-beta1, C4a, and MMP-9, alongside drastically depleted levels of Melanocyte Stimulating Hormone (MSH) and Vasoactive Intestinal Polypeptide (VIP)