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They're contraindicated in anyone with a personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2 [3][4]

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However, clinical trials on GLP-1RAs usually do not last for more than a year ..." Kidney, Cancer Risks Are Also Concerning The long-term risks of semaglutide are unknown, but already the drug carries a black box warning because rodent studies found semaglutide causes thyroid C-cell tumors "at clinically relevant exposures." 26 Pancreatic cancer is another concern