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Another study found that treatment with metformin can regulate the immune response in the intestines of mice by altering the composition of the gut microbiome, particularly through the downregulation of the NF-B signaling pathway ( Metformin has been shown to have some anti-inflammatory effects in clinical studies in patients with T2DM, in experimental studies in rodent models of obesity and T2DM, and in vitro experiments with several immune cells (Foretz et al., 2019

A statistically significant increase in thyroid C-cell adenomas and a numerical increase in C-cell carcinomas were observed in males and females at clinically relevant exposures

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This discovery has led to several GLP-1 agonists being licensed as weight loss drugs, such as Saxenda pens