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Because there is no significant reduction in cardiovascular outcomes in patients who have diabetes without established CVD, patient-centered shared decision-making about adding an SGLT-2 inhibitor or a GLP-1 agonist for cardiovascular benefit is important and should emphasize the lack of firm data

Rather, it depends on the concentration of the substance and its associated risk for harm

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This ligand-directed approach reduces systemic toxicity, enhances drug bioavailability at the site of interest, and improves therapeutic outcomes, particularly in tumours with heterogeneous receptor expression profiles [117]