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To further confirm that MT exerts its effects through MT2, H1703 cells were treated with MEL-1A-R siRNA or MEL-1B-R siRNA to generate MT1 and MT2 knockdown cell lines

Moreover, the observed discrepancy in ED degree category improvement according to IIEF-6 or PSV outcomes might be accounted by the absence of patients with baseline severe ED according to IIEF-6 score, as per exclusion criteria, along with the presence of a proportion of patients with baseline severe vasculogenic ED, which were included in the study based on their baseline mildmoderate or moderate ED at IIEF-6 score, as per inclusion criteria

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(University of California, San Francisco, 2015)