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Difficulty digesting fat: While the body adapts, initially, larger amounts of dietary fat can be harder to process without the concentrated bile bursts from the gallbladder

If either or both of these values are over the recommended range then it would be a good idea to supplement with both folate as well as vitamin B12

[See Warnings and Precautions (5.5)

In contrast, our study prospectively assessed TL and the response to a single 8-week antidepressant trial and used SSRIs exclusively, which may represent a population and time course that is distinct from the historical responders identified in the Pisanu study