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Researchers determined this using transgenic mice, allowing them to turn off the GLP-1 in the brain to see what happens

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Phase 3 trials (the TRIUMPH programme, registered on ClinicalTrials.gov) are currently underway, evaluating retatrutide across broader populations including those with cardiovascular disease, type 2 diabetes, and obesity-related complications

What to Expect: Timeline of Mental Health Changes Understanding the timeline of psychological changes helps set appropriate expectations and recognize improvements as they occur