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20%30% of patients receiving high-dose cisplatin will develop AKI, whose core diagnostic features are acute elevation of serum creatinine and rapid decline of Glomerular Filtration Rate (GFR), and up to 40%100% experience hypomagnesemia (Manohar and Leung 2018)

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Although some small clinical studies suggest a positive effect of GHRH or GH replacement on cognition (32), there are insufficient data to recommend testing GH deficiency or GH administration solely for this purpose