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When endogenous insulin production is insufficient to compensate for increasing insulin resistance, serum glucose levels go up leading to a pre-diabetic state (fasting glucose levels of 100125 mg/dL and A1C 5.76.4%) and consequently to diabetes (fasting glucose levels 126 mg/dL and A1C 6.5%) (50, 65)

Chesterton, L

It is also crucial to determine whether small gains in muscle carnosine content above those generally shown, induced by manipulation of some of these modifiable factors, do indeed lead to worthwhile improvements in performance