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Since E2f1 plays a key role in both post-natal proliferation of cells (18) and early pancreas development by targeting Pdx1 and Ngn3 expression through the Cdk4 pathway (19), the deletion of the E2f1 gene using Rip-Cre mice may affect early -cell differentiation and mass

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Additionally, EGCGs antioxidant properties help combat increased oxidative stress in HD neurons by directly scavenging ROS and upregulating endogenous antioxidant systems through Nrf2 pathway activation