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They are best viewed as one component of a comprehensive conservative treatment strategy

Irritability and Anxiety Poor sleep Gross motor problems or problems with coordination Tics Seizures (including absence seizures) If the child has untreated CFD, seizures may start at puberty Problems with vision Developmental delay and/or slowing of typical development Smaller head circumference (but certainly not always) Rett Syndrome maybe in indicator of CFD Depression *Not all these symptoms are seen in kids with CFD What Causes Cerebral Folate Deficiency

4.2.2 Methodological limitations 4.2.2.1 Study design challenges A PCB occupational exposure study involving 89 workers exemplifies common methodological limitations that can obscure true exposure-response relationships

Grifoni A, Sidney J, Vita R, Peters B, Crotty S, Weiskopf D, Sette A