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Additionally, metformin has been utilized for alleviating OA symptoms through various mechanisms, including anti-inflammation, activation of autophagy, inhibition of osteoclast activation, and regulation of chondrocyte aging 21,22,23,24

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DOI: 10.1016/S0968-0004(02)00003-8 47

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11 Humans risk overexposure from environmental concentrations that occur naturally (eg, arsenic-rich mineral deposits) or human activities (eg, lead or mercury release as a result of industrial pollution)

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J Biol Chem 272(19):1274712753 Gnanasekaran P, Ponnusamy K, Chakraborty S (2019) A geminivirus betasatellite encoded betaC1 protein interacts with PsbP and subverts PsbP-mediated antiviral defence in plants

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