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The result suggested a significant decrease in the extent of coronary plaques with low-attenuation area (a type of vulnerable plaques prone to rupture) (99, 100) with aged garlic extract compared to placebo, but no differences in total plaque volume and proportions of non-calcified plaques and dense calcium were found between treatment and placebo groups (98)

Designing a Rational Supplement Protocol In order to understand what a rational supplement protocol looks like, Huberman says that individuals should take a step back and ask themselves, What are different supplements designed to do? Foundational Supplements and Single Ingredient Formulations Among the myriad of supplements available, Huberman recommends that individuals first hone in on foundational supplements, which he says help ensure were getting all we need for a basic level of mental health, physical health, and performance

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Its one of the reasons why supplement-drug interactions can be dangerous and, in rare cases, even life-threatening