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Under normal conditions, iron absorption and distribution are controlled by hepcidin, a liver-derived hormone that serves as the master regulator of iron homeostasis

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While mild kidney or liver issues typically dont require dose adjustments, moderate to severe cases may warrant a more cautious approach with extended time at lower doses

These benefits were highlighted in 2019 when the Lancet published a meta-analysis of seven clinical trials showing that these treatments reduced hospital admission by 9%, all-cause mortality by 12% and deaths associated with kidney disease by 17% (Wilding et al., 2021)