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ChEBI chemical record Khavinson V, et al

Due to having the activated acetyl group, acetyl L-carnitine also activates nerve growth factor receptors (NGFRs) to enhance the alibility of nerve cells

Phase 2 trial data (published in New England Journal of Medicine, 2023 ): 24.2% average weight loss at 48 weeks with 12 mg dose 22.8% with 8 mg dose Placebo group lost 2.1% Most recent Phase 3 trial data (TRIUMPH-4, December 2025): 28.7% average weight loss at 68 weeks with 12 mg dose 26.4% with 9 mg dose 58.6% of participants on 12 mg achieved at least 25% weight loss 39.4% achieved at least 30% weight loss For context: These are the highest weight loss numbers reported in any clinical trial for a pharmacological obesity treatment

The company has committed more than $20 billion to building, expanding, and acquiring manufacturing facilities globally since 2020