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More recently it has been reported that the expression level of Nogo-B is upregulated in hepatocellular carcinoma and Nogo-B deficiency suppressed the tumor growth and metastasis [221]

In a multicellular organism, TLs are highly heterogeneous across different tissues and cell types depending, at least partly, on the tissue-specific proliferation rate, but they generally tend to decrease with age in all proliferating tissues (Demanelis et al., The size of critically short (uncapped) telomeres may be stabilized by telomerase, a reverse transcriptase enzyme that can elongate chromosome ends de novo

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doi:10.1016/j.gene.2016.05.018 165