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84,85 In a crossover study of healthy dogs taking the steroid prednisolone, SAMe supplementation at 10 mg/kg body weight twice daily for 42 days was found to reduce blood markers of liver oxidative damage, although the dogs still developed signs of steroid-induced liver disease

Their compounding was permitted only as a temporary, shortage-driven exception, and that exception has now closed

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"Effect of epitalon on interleukin-1 signal transduction and the reaction of thymocyte blast transformation under stress." Bulletin of Experimental Biology and Medicine