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Induction of this biosynthetic pathway enhances intracellular GSH levels and promotes cancer cell resistance to ferroptosis, 142,143 whereas pharmacological inhibition of GSH synthesis by L-buthionine-(S,R)-sulfoximine (BSO), a GCL inhibitor, induces ferroptosis 144

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Molecular Composition and Mechanistic Profile Mechanistically, Cagrilintide: Acts as a nonselective agonist at amylin receptors (AMY1R, AMY2R, AMY3R) and the calcitonin receptor (CTR), all of which are CTR/RAMP heterodimers in the calcitonin receptor family