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The transcription factor cAMP response element modulator (CREM) is highly expressed in male germ cells and regulates the expression of several post-meiotic genes, such as the transition proteins and protamines, and it likely is the key regulator of gene expression during spermatogenesis

Figure 3 To determine if the inhibition of proliferation is mediated by impaired DNA or RNA synthesis, we assessed the inhibition of DNA and RNA synthesis by the incorporation of exogenous radioactive thymidine and uridine ( Supplemental Figure 4 )

Post-treatment care is important for maximizing benefits

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