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KEAP1 modifies NRF2 via specific cysteinyl residues, leading to the ubiquitination of NRF2 for proteasomal degradation

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The test reveals genetic predispositions in Phase II detoxification and antioxidant pathways, which may contextualize whether supplemental glutathione or milk thistle addresses a meaningful metabolic need

Metabolic phenotyping For the glucose tolerance tests, mice were fasted for 2 h (beginning at ZT0) and then administered glucose via oral gavage (2.5 g kg 1 body weight)