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More importantly, the hazard ratio for major adverse cardiovascular events (including cardiovascular death, myocardial infarction, stroke, or hospitalization for unstable angina) for the pooled tirzepatide groups versus glargine was 0.74 (95% CI 0.511.08), suggesting no increased cardiovascular risk with tirzepatide compared to insulin glargine
Heres what they found: There was a higher risk of premature birth but only in women using GLP 1 to treat diabetes
Effectiveness : Because the approved weekly formulations rely on specific release mechanisms, changing the schedule may actually reduce appetite control the exact opposite of the intended effect
A separate 2024 study of 290 adults with obesity given oral semaglutide for three months found that free T3 decreased, free T4 rose slightly, and TSH fell during treatment
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