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Genetic, environmental, and psychological factors are implicated in its causation

Some patients report a metallic taste when using oral formulations, though this affects fewer than 8% of users and diminishes with continued use

Symptoms of vitamin B12 and folic acid deficiency anemia include: Shortness of breath Headache Indigestion Loss of appetite Heart palpitations Vision problems Feeling weak or tired Diarrhea Pain or redness of the tongue, sometimes with mouth sores Problems with memory, comprehension, and judgment (cognitive changes) Some of these symptoms may also occur in people who are deficient in vitamin B12 or folic acid but are not anemic

The reduction of MYCN protein levels in MYCN-driven brain tumors is of major importance due to its central role as an oncogenic driver (71)