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Mitochondrial iron metabolism and neurodegenerative diseases

10.2147/TCRM.S67076 34

Rapamycin exerts anti-ferroptotic effects by decreasing transferrin receptor expression, reducing cellular iron content, and activating the iron-regulated protein-1/2 (Irp1/2) system, potentially compensating for transferrin downregulation to maintain iron homeostasis (69)

Short-term inflammationwhich can happen, say, after eating a high-sodium mealcan lead to temporary water retention and unwanted puffiness, but this usually fades once the trigger passes