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While dehydration plays a role, drinking alcohol triggers a cascade of physiological disruptions that water alone cannot fix

Circulation 146(5):372379

If concomitant use is warranted, consider recommending or prescribing an opioid overdose reversal agent (see WARNINGS, Life-Threatening Respiratory Depression

Furthermore, fluoxetine was found to lower GR expression in the hippocampal CA2 and CA3 regions and to reduce the density of glutamate receptor interacting protein 1 in the hippocampal CA1 region of prepubertal and adolescent individuals (17,19)