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In accordance with the international recommendations, bone formation marker procollagen type I intact N-terminal propeptide (P1NP) and bone resorption marker collagen type I C-telopeptide (CTX) were generated using commercially available chemiluminescence protocols (Immunodiagnostics Systems, The Boldens, United Kingdom), as conducted previously (Wherry et al., 2019)

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The delayed gastric emptying characteristic of these therapies frequently causes gastrointestinal adverse effects, particularly nausea, vomiting, and diarrhea