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Institutional Review Board Statement The study was conducted according to the guidelines of the Declaration of Helsinki and approved by the Institutional Review Board of Tufts University Health Sciences Campus (Protocol #12347, approval date 23 January 2017)

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The absorption of monoglutamate forms occurs mostly by a saturable mechanism via the reduced folate carrier, folate receptor, and especially proton-coupled folate transporter with Km of 13 M 881,890,891