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It is noteworthy that, although Vitamin D supplementation within the recommended intake range is generally safe, Vitamin D intoxication has increasingly drawn attention in the context of prolonged or intermittent high-dose regimens, with severe hypercalcemia as the central mechanism leading to neurological, gastrointestinal, cardiovascular, and renal complications [267]

In the ischemia/reperfusion-induced fibrosis C57BL/6J mouse model, transcriptomic and metabolomic analyses showed that dapagliflozin treatment mitigated accumulation of tricarboxylic acid (TCA) circulating metabolites and up-regulation of inflammation in fibrotic renal cortical tissue