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The main efficacy-related conclusions of this review are: (a) medications demonstrated the strongest and most consistent effects on core ADHD symptoms (especially inattention), (b) heterogeneous C/BTs demonstrated inconsistent effects on ADHD symptoms, strong consistent effects on impairment and executive function skills, and modest consistent effects on internalizing symptoms and analogue note-taking performance, (c) C/BTs demonstrated consistent maintenance effects for executive function skills and impairment up to 6 months and possibly 3 years post-treatment, (d) though comparing the efficacy of two C/BTs rarely led to significant differences, which C/BT worked best for whom could be reliably predicted from patient- and provider-level moderators

Minimum effective frequency is 4 applications per week

LC controls pyruvate dehydrogenase activity by interacting with acetyl-CoA and maintaining acetyl-CoA/CoA ratios in the cell [359, 361]

Aceetyl L-Carnitine 400 is an ultra-high potency source of Acetyl L-Carnitine (ALC), which has long been recognized for its essential role in all fat and energy metabolism as well as healthy brain function