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Therefore, modulating copper homeostasis and cuproptosis addresses a novel pathogenic axis that is not directly targeted by existing first-line drugs, suggesting the potential for synergistic or personalized therapeutic strategies

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A novel pentadecapeptide, BPC 157, blocks the stereotypy produced acutely by amphetamine and the development of haloperidol-induced supersensitivity to amphetamine

Consistently, given the close BPC 157/NO-system relations (see Chapter NO), these should be overseen with the evidence that the gasotransmitters can cross the cell membrane and act directly on molecules inside the cell [36], and thereby, particularly interacting with receptors on the plasma membrane of their target cells can be envisaged