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Try the BMI Calculator Table of contents The two mechanisms: why GLP-1 medications create a hydration deficit The clinical data on dehydration rates in tirzepatide trials The three-phase dehydration timeline: when risk peaks and when it resolves Why thirst is an unreliable signal on Zepbound Symptoms of dehydration vs symptoms of normal titration The FormBlends Hydration Protocol: baseline calculation plus offset Risk factors that multiply dehydration vulnerability Electrolyte loss: when water alone isn't enough What most articles get wrong about GLP-1 dehydration When reduced urination means dehydration vs kidney concern The rehydration protocol for symptomatic patients When to call your provider FAQ The two mechanisms: why GLP-1 medications create a hydration deficit Zepbound's active ingredient, tirzepatide, creates dehydration risk through two independent pathways that compound each other