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No direct comparative safety or tolerability data exist for GLP-1 RAs specifically in MC4R -deficient populations, nor are there systematic comparative studies in this group

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From Phase 2 to Phase 3: how the story developed The Phase 2 NEJM study (Jastreboff 2023) The modern retatrutide story begins with Jastreboff AM et al., published in the New England Journal of Medicine in 2023 (DOI 10.1056/NEJMoa2301972)