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ADCs with branched PEG chains (e.g., PEG24) demonstrate lower hydrophobicity, extended circulation time, and superior anti-tumor activity compared to non-PEGylated variants (Figure 15)

Batista AF, Forny-Germano L, Clarke JR, Lyra ESNM, Brito-Moreira J, Boehnke SE, et al

These crystals create mechanical forces at the molecular level that can physically break apart large peptide molecules like semaglutide

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