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Methylcobalamin is the active form of vitamin B12 that can be directly utilized by the body, bypassing the need for conversion

At the metabolic interface, oxidative stress impairs the Nrf2 antioxidant defense system and compromises mitochondrial membrane integrity [113, 114], while emerging non-apoptotic cell death pathwayssuch as ferroptosis (GPX4/ACSL4) and necroptosis (RIPK1/3MLKL)drive follicular demise in toxin-exposed or inflamed ovaries [79, 115]

Fold changes were calculated from the Generalized Linear Model GLM, which corrects for differences in library size between the samples and the effects of confounding factors

The effect of ovarian reserve and receptor signalling on granulosa cell apoptosis during human follicle development