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GLP-1 receptors have been identified within myocardial tissue and autonomic centres [21,22,23], with murine studies demonstrating effects on heart rate, endothelial function and regulation of the autonomic nervous system [24,25,26]

The risk of urinary tract infections increased in patients who were 75 years of age and older to 10.5%, 15.7%, and 15.1% in patients randomized to placebo, JARDIANCE 10 mg, and JARDIANCE 25 mg, respectively [see Warnings and Precautions (5.2) and Adverse Reactions (6.1)]

et al., The Journal of Physiology 4

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