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Metformin affects macrophages' phenotype and improves the activity of glutathione peroxidase, superoxide dismutase, catalase and decreases malondialdehyde concentration in a partially AMPK-independent manner in LPS-stimulated human monocytes/macrophages

In addition to its direct antioxidant effects, glutathione stimulates the bodys other antioxidant enzymes , including glutathione peroxidase and catalase, enhancing their efficacy