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And further, the area is assessed for the presence of any additional tumor tissues or cells at the excised location [138]

It will require clinical trials by independent entities to delineate the true effectiveness and side effect profile of this and all new medications. Following the results of earlier trials, Novo Nordisk submitted a New Drug Application to the Food and Drug Administration (FDA) in December 2025 for the use of CagriSema to assist and maintain weight loss alongside diet and exercise adjustments

International guidelines recommend the use of GLP-1 analogues in T2DM patients with ASCVD or who have high cardiovascular risk [44, 45]