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Las limitaciones de esta revisin radican en la diferencia del diseo de los diferentes estudios, as como en las dosis de carnitina utilizadas (rango de 8 a 48 mg/kg/da) o duracin de la suplementacin

CHAC1 is involved in the stress-induced apoptosis of -cells, contributing to the progression of both type 1 and type 2 diabetes by impairing insulin production ( In muscle-wasting conditions like cancer cachexia, CHAC1 exacerbates oxidative stress by degrading GSH, thereby accelerating muscle degradation and protein breakdown (Li et al., 2023)

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While SUSTAIN-6 and REWIND trials examined GLP-1 RA in diabetics with different cardiovascular risk profile, The Harmony Outcomes study enrolled patients with T2D and established atherosclerotic cardiovascular disease (ASCVD)