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In one single-center trial of 72 subjects using a controlled-adverse-environment model, the T4 eye drop did not meet its co-primary endpoints (ocular discomfort and inferior corneal staining) at the primary time point, but it did produce statistically significant improvements on several secondary endpoints, including central and superior corneal staining, with no adverse events reported
In real-world terms, that means patients are not using it because they think it is another acne medicine
These effects typically intensify at doses above 10 mg daily and can last weeks after discontinuation
Then, acetonitrile was added at 85 C until the components were dissolved completely
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