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Even healthy individuals are instructed not to take more than one dose within 24 hours, and no more than 8 doses per month, to avoid excessive strain on the cardiovascular system

However, other investigations have suggested that several GLP-1RAs may cross the bloodbrain barrier via passive diffusion 251 , a GLP-1R-mediated uptake mechanism 252 or adsorption transcytosis 253 , although different compounds may present with variable degrees of brain penetrance 254

After your injection, pressing firmly on the site for at least two minutes can help minimize this