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Clinical trials establishing the efficacy of these medications, including the STEP trials for semaglutide and the SURMOUNT trials for tirzepatide, all paired pharmacotherapy with structured lifestyle interventions, such as dietary counseling and physical activity targets

D. C. Morris, M. Chopp, L. Zhang, and Z. G. Zhang, Thymosin 4: a candidate for treatment of stroke?, Wiley, May 2010. doi: 10.1111/j.1749-6632.2010.05469.x

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And, you know, I think its really its a bit treacherous if were out talking about things that arent rooted in fact and are based on guts, and hunches, and feelings, and personal experiences, which is fine, but if were making decisions on stuff, we really kind of have to do two things: 1., we have to separate church and state as much as possible thats one way to think about it and 2nd, we have to just stay tethered to science and fact