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Among the compounds that the enzyme reduces there are phospholipids, fatty acids and DNA hydroperoxides produced by lipid peroxidation and oxidative damage to DNA 1

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Other sirtuins, including SIRT2, SIRT4, SIRT5 and SIRT6, have a K m for NAD + below the physiological range, implying that NAD + might not necessarily be the rate-limiting of their activity