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Current guidelines for the treatment of diabetes and obesity recommend a step-wise approach starting with lifestyle interventions aimed at body weight loss, an increase in physical activity, and additional measures for healthier choices in everyday decisions and habits
Conversely, when this framework is extended to reproductive endpointswhich are subject to greater definitional heterogeneity and effect modificationthe appearance of long-tailed distributions suggests that the quantified probability of efficacy may not demonstrably exceed that of metformin
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Often, the rise in obesity is explained as being due to people eating more and food being more appealing
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