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Description

Inactivation mechanism of N61S mutant of human FMO3 towards trimethylamine

The fundamental difference relative to apoptosis is the rapid loss of cellular membrane potentials due to energy depletion and ion pump/channel failures, leading to swelling, rupture, and cytolysis

EC 50 =447 and 529 nM, for -arrestin 1 and -2 recruitment, respectively), when compared with the reference agonist Ex4 (EC 50 =29.57 and 5.6 nM for -arrestin 1 and -2 recruitment, respectively